Solid-phase total synthesis of cyclic pentapeptide Longicalycinin A, by using 2-chlorotrityl chloride resin
نویسندگان
چکیده
منابع مشابه
Synthesis of linear and cyclic disulfide heptapeptides of Longicalycinin A and evaluation of toxicity on cancerous cells HepG2 and HT-29
In this work, linear and cyclic disulfide heptapeptides of Longicalycinin A have been successfully synthesized by solid phase methodology with Fmoc /t-Bu and solution phase, respectively. 2-Chlorotrityl chloride resin (2-CTC) was used as a solid support. The synthesized linear disulfide analogue of Longicalycinin A was cleaved from the resin as a protected peptide. The final deprotection was pe...
متن کاملSynthesis of linear and cyclic disulfide heptapeptides of Longicalycinin A and evaluation of toxicity on cancerous cells HepG2 and HT-29
In this work, linear and cyclic disulfide heptapeptides of Longicalycinin A have been successfully synthesized by solid phase methodology with Fmoc /t-Bu and solution phase, respectively. 2-Chlorotrityl chloride resin (2-CTC) was used as a solid support. The synthesized linear disulfide analogue of Longicalycinin A was cleaved from the resin as a protected peptide. The final deprotection was pe...
متن کاملUse of an internal reference for the quantitative HPLC-UV analysis of solid-phase reactions: a case study of 2-chlorotrityl chloride resin.
Here we evaluated the use of internal reference compounds for the rapid assessment of reactions performed in solid-phase. An internal reference compound (commercially available) was bound to the resin, together with the substrate, and cleaved with the products after completion of the reaction. The peak area of the reference compound in the HPLC-UV chromatograms can be correlated directly with t...
متن کاملPreparation of 2-(Propylamino)Ethanethiol 2- Chlorotrityl (PAET) Resin for the Synthesis of Peptide Thioesters
The preparation of peptide thioesters using Fmoc chemistry requires their synthesis as amides flowed by an N -> S-acyl shift reaction. Recently, bis(2-sulfanylethyl)amino-trityl-polystyrene (SEA) resin has been reported (1, 2), where the peptide is synthesized as a secondary amide, and the N -> S-acyl shift occurs by reaction of one of the two 2-sulfanylethyl groups. The PAET resin described he...
متن کاملA total solid-phase synthesis of DILP8.
We have developed a cysteine anchoring method for the synthesis of DILP8 and its analogues. The first is to synthesis of DILP8A SS13-18, C14-MeOBzl, C24-Acm and activate it as DILP8A S13-18, C14-SSPyr C24-Acm. A next step is to synthesize the DILP8BC16-Acm. The desired peptide, DILP8 with Cys(Acm) at A-24 and B-16, was then dissolved in 75% HOAc by addition of Iodine in MeOH and 4M HCl in dioxa...
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ژورنال
عنوان ژورنال: Journal of Cancer Research and Experimental Oncology
سال: 2013
ISSN: 2141-2243
DOI: 10.5897/jcreo2013.0102